The influence of diabetes mellitus on periodontal tissues: a pilot study
엄유정, 정의원, 김창성, 박은정, 차정헌, 유윤정, 최성호,
소속 상세정보
엄유정 ( Um Yoo-Jung ) - 연세대학교 치과대학 치주과학교실
정의원 ( Jung Ui-Won ) - 연세대학교 치과대학 치주과학교실
김창성 ( Kim Chang-Sung ) - 연세대학교 치과대학 치주과학교실
박은정 ( Park Eun-Jung ) - 연세대학교 치과대학 구강생물학교실
차정헌 ( Cha Jeong-Heon ) - 연세대학교 치과대학 구강생물학교실
유윤정 ( Yu Yoon-Jeong ) - 연세대학교 치과대학 구강생물학교실
최성호 ( Choi Seong-Ho ) - 연세대학교 치과대학 치주과학교실
KMID : 0363020100400020049
Abstract
Purpose: The purpose of this study was to preliminarily evaluate the influence of diabetes mellitus (DM) on periodontal tissue without establishment of periodontitis.
Methods: Seven-week-old db/db mice were used for the diabetic experimental group and systematically healthy mice of the same age were used as controls. After 1 week of acclimatization, the animals were sacrificed for hard and soft tissue evaluation. The pattern of bone destruction was evaluated by stereomicroscope evaluation with alizarin red staining and radiographic evaluation by microscopic computerized tomography images. Histological evaluation was performed with hematoxylin and eosin stain for evaluation of soft tissue changes.
Results: In both stereomicroscope evaluation and radiograph image analysis, aggressive form of bone destruction was observed in diabetic animals when compared to the systematically healthy controls. In histological evaluation, apical migration of junctional epithelium with slight inflammatory cell infiltration was observed with disarrangement of connective tissue fibers.
Conclusions: Within the limits of this study, diabetic animals presented distortion in periodontal attachment and an aggressive bone loss pattern when compared to the healthy controls, suggesting that DM has an independent effect on periodontal tissue destruction irrespective of the presence or absence of periodontal disease.
키워드
Diabetes mellitus;Inflammation;Periodontal disease
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